In Vitro and Biomarker Capabilities

Focusing on strategic assay validation and study design enables Piedmont Research Center to provide reliable biological translation to our clients’ preclinical programs.

Through our technical and facility infrastructure as well as our design expertise, we develop the appropriate in vitro platform to service clients’ in vitro and biomarker needs.

In Vitro Capabilities

• Basic growth inhibition assays with IC50 determination
• Combination analysis using the Chou-Talalay fixed ratio experimental design
• Protein/phosphoprotein analysis using standard western blot techniques and a multiplex bead-based platform
• Plate-based apoptosis assays

Biomarker Capabilities

• Tumor profiling for target expression and modulation; choose the right model for your particular test agent
• Tumor sampling throughout your in vivo preclinical study to monitor for target modulation
• Cytokine analysis using a multiplex bead-based platform
• Immunohistochemistry capabilities