Cachexia Model

Development of cachexia is a very common complication associated with many human cancers. The Yoshida ascites hepatoma model induces cachexia and produces tissue wasting, particularly in skeletal muscle. This very aggressive, short-term model is used to evaluate the anti-cachectic effects of therapy. With therapies typically beginning on day one and continuing to end of study, heart, gastrocnemius and ascites are measured at sacrifice and used to evaluate efficacy of therapy.