The need to improve medicines for children is driving greater efforts to include children in the drug development process. The number of pediatric clinical trials is increasing in response to new regulation, increased funding and scientific advances in therapeutic areas of special benefit for children. This emerging research environment offers unprecedented opportunities to address the unique challenges posed by evaluating new therapies in pediatric populations.
In this paper, the authors discuss the need for a pediatric research community that can provide expertise to advance pediatric trial design and methodologies. They discuss pediatric research challenges and describe PPD’s Pediatric Investigator Network (PIN), a network of 12 pediatric centers of excellence established to share scientific thinking, improve pediatric study design and implementation, and communicate knowledge and research approaches across the international pediatric research community.